5 Essential Elements For akorn promethazine codeine
5 Essential Elements For akorn promethazine codeine
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Suggest clients to avoid participating in hazardous tasks demanding mental alertness and motor coordination soon after ingestion of promethazine HCl and codeine phosphate oral Option. Stay clear of concurrent utilization of promethazine HCl and codeine phosphate oral Option with alcohol or other central anxious method depressants simply because extra impairment of central nervous procedure performance may possibly occur [see Warnings and Safeguards (five.10)].
g., amiodarone, quinidine) may possibly lead to an increase in codeine plasma concentrations plus a minimize in Lively metabolite morphine plasma focus which could lead to an analgesic efficacy reduction or signs of opioid withdrawal.
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The phosphate salt of codeine occurs as white, needle-formed crystals or white crystalline powder. Codeine phosphate is freely soluble in water and slightly soluble in alcohol. The molecular weight is 406.37. Its molecular components is C18H21NO3•H3PO4 • ½ H2O, and it's got the following chemical construction.
Make contact with community state Specialist licensing board or condition controlled substances authority for information on how to avoid and detect abuse or diversion of this products.
Promethazine HCl and codeine phosphate oral Resolution must be employed with caution in individuals with impairment of hepatic perform, and clients need to be monitored closely for respiratory melancholy, sedation, and hypotension.
Reproductive toxicity studies haven't been executed with promethazine HCl and codeine phosphate oral Resolution; on the other hand, scientific tests can be found with unique Energetic components (see Data).
As an example, a lot of noted conditions of death occurred in the put up-operative interval adhering to tonsillectomy and/or adenoidectomy, and a lot of of the youngsters had evidence of staying extremely-swift metabolizers of codeine. Furthermore, youngsters with obstructive snooze apnea who're handled with codeine for write-up-tonsillectomy and/or adenoidectomy discomfort could be notably delicate to its respiratory depressant influence. Due to risk of lifetime-threatening respiratory melancholy and Loss of life:
Use caution When thinking about the use of promethazine HCl and codeine phosphate oral Answer in individuals 65 a long time of age or older.
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We anticipate reposting the pictures when we've been capable determine and filter out images that do not match the data offered in the drug labels. NDC Codes
Promethazine Promethazine competitively antagonize H1 receptors located in many of the smooth muscle such as the gastrointestinal tract, uterus, significant blood vessels and bronchial muscle.
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Bodily dependence, the affliction during which ongoing administration in the drug is necessary to avoid the appearance of a withdrawal syndrome, assumes clinically considerable proportions only following various months of ongoing oral opioid use, Though some gentle degree of physical dependence could create immediately after a few days of opioid therapy.